New Daily Persistent Headache Biomarkers Study

  • STATUS
    Recruiting
  • participants needed
    240
  • sponsor
    Albert Einstein College of Medicine
Updated on 19 February 2024

Summary

New daily persistent headache is a debilitating syndrome which is seldom researched, poorly understood, and without effective treatments. Chronic migraine is a more common but similarly disabling disorder. The goal of this study is to evaluate the blood levels of two proteins involved with pain signaling; calcitonin gene-related peptide (CGRP) and nerve growth factor (NGF).

CGRP levels are known to be elevated in chronic migraine, and recent phase 2 clinical trials suggest that treatments targeting CGRP are safe and effective for treatments for migraine. If CGRP levels are elevated in the blood of people with new daily persistent headache, future studies will be designed to evaluate whether treatments that target CGRP are effective in treating new daily persistent headache. If NGF levels are elevated in the blood of patients with new daily persistent headache and/or chronic migraine, future studies will be designed to evaluate whether treatments that target NGF antibodies (targeted treatments against NGF) are effective in treating NDPH and/or chronic migraine.

Details
Condition New Daily Persistent Headache, New Daily Persistent Headache (NDPH)
Age 18years - 75years
Clinical Study IdentifierNCT04260087
SponsorAlbert Einstein College of Medicine
Last Modified on19 February 2024

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