Epidemiologic and Clinical Characteristics of Optic Neuritis in China

  • STATUS
    Recruiting
  • participants needed
    1000
  • sponsor
    Chinese PLA General Hospital
Updated on 19 February 2024
optic neuritis

Summary

This will be a hospital-based retrospective multi-center study on epidemiologic and clinical characteristics of optic neuritis among Chinese. The investigation will cover about 29 provinces or municipalities all around China.

Description

This national investigation will be conducted to describe the epidemiology and clinical characteristics of optic neuritis in China. All the patients will be divided into 3 groups according to the serum demyelinating antibodies (Aquaporin-4 antibody seropositive group, Myelin oligodendrocyte glycoprotein antibody seropositive group and double seronegative group). The investigator will analyze the differences among the three groups.

Primary outcomes:

  • To dig out the different visual acuity (VA, LogMAR) prognosis among the three groups;
  • To calculate the annual relapse rate (ARR) differences among the three groups (relapse times in all the follow-up time in each group/ follow-up time (years) in all in each group).

Secondary outcomes:

  • Other epidemiological and clinical characteristics of optic neuritis patients will be analyzed among the three groups;
  • Orbital or Brain MRI is required in this study, which could avoid the misdiagnosis. We will collect and analyze these MRI data too (including the optic nerve lesions in T2 weight images and T1 enhanced MRI);
  • Results of optical coherence tomography (OCT) (including peripapillary retinal nerve fiber layer, macular thickness ,and ganglion cell and inner plexiform layer complex) at different time point are also needed in this study. However, OCT is not necessarily required;
  • Visual fields at different time points are also encouraged to provide if they are available.

Details
Condition Optic Neuritis
Age 100years or below
Treatment Observation
Clinical Study IdentifierNCT04257734
SponsorChinese PLA General Hospital
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of optic neuritis
The patients' medical records were complete

Exclusion Criteria

Patients with unclear diagnosis of optic neuritis
Incomplete medical records
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    Chinese PLA General Hospital

    China

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Investigator Avatar
Mo Yang, PhD

Primary Contact

site
Chinese PLA General Hospital

China

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