Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors
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- STATUS
- Recruiting
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- participants needed
- 170
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- sponsor
- Immunocore Ltd
Summary
IMC-F106C is an immune-mobilizing T cell receptor against cancer (ImmTAC ) designed for the treatment of cancers positive for the tumor-associated antigen PRAME. This is a first-in-human trial designed to evaluate the safety and efficacy of IMC-F106C in adult patients who have the appropriate HLA-A2 tissue marker and whose cancer is positive for PRAME
Description
The IMC-F106C-101 Phase 1/2 study will be evaluated in patients with metastatic/unresectable tumors which include select Advanced Solid Tumors and will be conducted in two phases.
- Phase 1: To identify the Maximum Tolerated Dose (MTD) and/or Recommended Phase 2 dose (RP2D) of IMC-F106C as a single agent (Arm A) and administered in combination with Checkpoint Inhibitors (Arm B).
- Phase 2: To assess the preliminary anti-tumor activity of IMC-F106C in up to 4 indications, as a single agent administration.
Details
| Condition | Select Advanced Solid Tumors |
|---|---|
| Age | 18years - 100years |
| Treatment | IMC-F106C, anti-PD(L)1 |
| Clinical Study Identifier | NCT04262466 |
| Sponsor | Immunocore Ltd |
| Last Modified on | 19 February 2024 |
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