The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia

STATUS

Recruiting
participants needed

90
sponsor

University of Illinois at Chicago

Send

Updated on 19 February 2024

See if I qualify

strength training

hypertension

resistance training

sarcopenia

Summary

Show definitions

Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal. This randomized control intervention pilot study will provide new evidence of the unexplored relationship between muscle strength and high BP in sarcopenia, and experimentally test the effects of an evidence-based progressive resistance training intervention on BP, while also examining reversibility to identify muscle strength as a non-pharmacological target for BP control in older sarcopenic adults.

Description

This premise of this K01 proposal is to address current gaps in the literature regarding the understanding of high blood pressure due to sarcopenia, and provide new evidence for the discernible relationship between low muscle strength and blood pressure in sarcopenia, and effective non-pharmaceutical treatment approaches. This study will evaluate the feasibility of recruitment, retention, implementation and adherence to an empirically-based progressive resistance training (PRT) intervention to test its effect on blood pressure in a targeted population of older adults with sarcopenia who are randomized (via block permuted scheme) to the PRT intervention. Built within this randomized control intervention design, the investigators will further explore reversibility to examine whether muscle strength serves as an intervention target for blood pressure control in sarcopenic adults, which will be more appropriately tested in subsequently well-powered R-level intervention studies. Physiologically plausible microvascular mechanisms by which the PRT impacts changes in blood pressure will also be explored.

Details

Condition	Vascular Diseases, Vascular Diseases, Hypertension, Sarcopenia
Age	65years - 100years
Treatment	Progressive Resistance Training
Clinical Study Identifier	NCT04255745
Sponsor	University of Illinois at Chicago
Last Modified on	19 February 2024

How understandable was the trial content above?

Hard to understand

Easy to understand

Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Adults (men and women) aged 65 years and older (any racial/ethnic background)
	Sedentary or low active adults (not active in strength training)
Exclusion Criteria
	Subjects with self-report of inability to walk at least mile or walk 400 meters in <15 minutes without sitting
	Subjects who self-reported having a history of a cardiovascular disease (CVD) event or physician diagnosed CVD (heart attack, heart failure, peripheral vascular disease, coronary revascularization, or angina that required overnight hospitalization)
	Subjects history of mental illness (bipolar, multiple personality disorder), or cognitive impairment (e.g., dementia, Alzheimer's)
	Subjects with orthopedic pathology or deformity that prevents exercising safely
	Subjects with active cancer (i.e., recent physician diagnosis, currently receiving treatment, or in remission)
	Subjects with lupus, multiple sclerosis
	Lidocaine allergy
	Participants from the same household as those already enrolled in the study
	Baseline Montreal Cognitive Assessment score of <22 (adjusted by adding 2 points for education 4-9, 1 point for education 10-12 years)
	Current participation in another exercise study
	Currently is- or has a history of abusing alcohol or illicit drugs
	Subjects who plan to move in the next 6 months or take an extended vacation
	Non-english speakers

How to participate?

Step 1 Connect with a study center

Send a message

Enter your contact details to connect with study team

First name*

Last name*

Email*

Phone number*

Other language

I am at least 18 years old.

By sending a message, I agree to share my information with the study team for the selected site and consent to receive emails and text messages for trial updates, notifications, and related communication. TrialX values your privacy; your information will be handled in accordance with our Privacy Policy

Step 2 Get screened

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

Step 3 Enroll in the clinical study

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Step 4 Get your study results

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia