The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia

STATUS

Recruiting
End date

Mar 28, 2025
participants needed

90
sponsor

University of Illinois at Chicago

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Updated on 19 February 2024

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strength training

hypertension

resistance training

sarcopenia

Summary

Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal. This randomized control intervention pilot study will provide new evidence of the unexplored relationship between muscle strength and high BP in sarcopenia, and experimentally test the effects of an evidence-based progressive resistance training intervention on BP, while also examining reversibility to identify muscle strength as a non-pharmacological target for BP control in older sarcopenic adults.

Description

This premise of this K01 proposal is to address current gaps in the literature regarding the understanding of high blood pressure due to sarcopenia, and provide new evidence for the discernible relationship between low muscle strength and blood pressure in sarcopenia, and effective non-pharmaceutical treatment approaches. This study will evaluate the feasibility of recruitment, retention, implementation and adherence to an empirically-based progressive resistance training (PRT) intervention to test its effect on blood pressure in a targeted population of older adults with sarcopenia who are randomized (via block permuted scheme) to the PRT intervention. Built within this randomized control intervention design, the investigators will further explore reversibility to examine whether muscle strength serves as an intervention target for blood pressure control in sarcopenic adults, which will be more appropriately tested in subsequently well-powered R-level intervention studies. Physiologically plausible microvascular mechanisms by which the PRT impacts changes in blood pressure will also be explored.

Details

Condition	Vascular Diseases, Vascular Diseases, Hypertension, Sarcopenia
Age	65years - 100years
Treatment	Progressive Resistance Training
Clinical Study Identifier	NCT04255745
Sponsor	University of Illinois at Chicago
Last Modified on	19 February 2024

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Inclusion Criteria
	Adults (men and women) aged 65 years and older (any racial/ethnic background)
	Sedentary or low active adults (not active in strength training)
Exclusion Criteria
	Subjects with self-report of inability to walk at least mile or walk 400 meters in <15 minutes without sitting
	Subjects who self-reported having a history of a cardiovascular disease (CVD) event or physician diagnosed CVD (heart attack, heart failure, peripheral vascular disease, coronary revascularization, or angina that required overnight hospitalization)
	Subjects history of mental illness (bipolar, multiple personality disorder), or cognitive impairment (e.g., dementia, Alzheimer's)
	Subjects with orthopedic pathology or deformity that prevents exercising safely
	Subjects with active cancer (i.e., recent physician diagnosis, currently receiving treatment, or in remission)
	Subjects with lupus, multiple sclerosis
	Lidocaine allergy
	Participants from the same household as those already enrolled in the study
	Baseline Montreal Cognitive Assessment score of <22 (adjusted by adding 2 points for education 4-9, 1 point for education 10-12 years)
	Current participation in another exercise study
	Currently is- or has a history of abusing alcohol or illicit drugs
	Subjects who plan to move in the next 6 months or take an extended vacation
	Non-english speakers

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The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia