Cancer Therapy Effects on the Heart

STATUS

Recruiting
End date

Sep 30, 2029
participants needed

60
sponsor

University of California, San Diego

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Updated on 19 February 2024

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cancer

metastasis

MRI

heart failure

daunorubicin

cancer treatment

doxorubicin

anthracyclines

cardiotoxicity

electrocardiogram

cancer therapy

diagnostic tests

childhood cancer

anthracycline

pediatric cancer

pediatric

Summary

Show definitions

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) is commonly given to treat pediatric cancer, and carries a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.

Description

Cardiac shape, function, and tissue characteristics will be examined using cardiac MRI data in combination with standard cardiac assessments (by echocardiography, electrocardiograms, and cardiac MRI) to assess the cardiotoxic effects of cancer therapy. Analyses will be performed in a cross-sectional cohort of adolescents and young adults with a history of childhood cancer.

Details

Condition	Heart failure, Heart failure, Heart disease, Heart disease, Breast Cancer - HER2 Positive, Pediatric Cancer, Chronic Shoulder Pain
Age	13years - 25years
Treatment	Electrocardiogram, Cardiac magnetic resonance imaging (MRI), Echocardiography
Clinical Study Identifier	NCT04262830
Sponsor	University of California, San Diego
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	English and Spanish speaking male and female subjects, ages 14-25 years old
	Previously treated for cancer, with diagnosis at least two years prior
	Patients whose cancer has recurred, persisted, is still detectable, or have developed a secondary cancer will still be eligible
Exclusion Criteria
	Patients who have a contraindication to contrast cardiac MRI, including the presence of non-MRI compatible metallic implants and severe renal dysfunction
	Medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would preclude the subject from undergoing the cardiac MRI without anesthesia
	Patients with a history of congenital heart disease (more significant than a history of patent foramen ovale or patent ductus arteriosus)
	Patients with orthodontic braces or metallic implants in the thorax or abdomen/lumbar spine, even if MRI-compatible, will be excluded as these may cause artifacts and limit image quality
	Females who are pregnant

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Cancer Therapy Effects on the Heart