Comparison of High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy for the Treatment of Localized Prostate Cancer
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- STATUS
- Recruiting
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- participants needed
- 10
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- sponsor
- Rutgers, The State University of New Jersey
Summary
This phase II trial compares high-dose rate brachytherapy and stereotactic ablative radiotherapy as monotherapy in treating patients with prostate cancer that has not spread to other parts of the body (localized). High-dose rate brachytherapy delivers radiation directly into the prostate within a few minutes by a single radioactive seed through temporarily placed plastic catheters inside the prostate gland. Stereotactic ablative radiotherapy is an external beam radiation method that delivers large doses of radiation to the cancer in a short period of time, usually 5 treatments. This trial aims to find which of these two approaches is better in terms of patient-reported quality of life.
Description
PRIMARY OBJECTIVE:
I. To assess feasibility of a pilot randomized trial evaluating stereotactic ablative radiotherapy (SABR) and high-dose rate brachytherapy for localized prostate cancer.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients undergo high-dose rate brachytherapy (HDR).
ARM II: Patients undergo SABR every other day for 5 treatments.
After completion of study treatment, patients are followed up periodically.
Details
| Condition | Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8, Stage IIB Prostate Cancer AJCC v8, Stage IIC Prostate Cancer AJCC v8 |
|---|---|
| Age | 18-100 years |
| Treatment | Questionnaire Administration, Quality-of-Life Assessment, High-Dose Rate Brachytherapy, Stereotactic Ablative Radiotherapy |
| Clinical Study Identifier | NCT04253483 |
| Sponsor | Rutgers, The State University of New Jersey |
| Last Modified on | 19 February 2024 |
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