Prospective Longitudinal Observational Research in Atopic Dermatitis

STATUS

Recruiting
participants needed

1000
sponsor

University of Zurich

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Updated on 19 February 2024

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rhinitis

asthma

food allergy

atopy

allergic asthma

skin disorder

dermatitis

allergic rhinitis

eczema

atopic dermatitis

Summary

Atopic dermatitis (AD) is a frequent chronic relapsing inflammatory skin disorder, characterized by intensely itchy eczema. AD usually starts within the first 2 years of life. In 30 - 60% of children, inflammation spreads onto other body surfaces such as the gastrointestinal tract, the respiratory tract, and the conjunctives within a few years. This sequence is called atopic march.

Atopic dermatitis and associated atopic diseases are more frequent in families, suggesting a genetic predisposition. However, the underlying factors such as genetic phenotype, environmental factors, or life style which cause or worsen an existing allergic disease are not understood yet. Affected people suffer from recurrent flares that result in significantly impaired quality.

This study will collect clinical and laboratory data to elucidate immunotolerance and preventiv stategies with the aim to develop new and individual treatment options of atopic diseases.

Description

Primary Objetive:

In the planned project, the main objective is to identify endogenous (e.g. immunological and molecular factors) and exogenous factors (e.g. environmental, socioeconomic and microbial factors) that influence the course and remission of AD. More specifically to identify factors that are significantly different between patients that have or do not have remission from AD.

Secondary Objective:

(i) To identify endogenous and exogenous factors such as immunological, molecular and microbial factors to separate subgroups of patients (endotypes) with distinct local and systemic inflammatory responses.

(ii) To identify potential biomarkers predicting the individual clinical course of AD and other atopic diseases including asthma, food allergy and allergic rhinitis.

Details

Condition	ATOPIC DERMATITIS, eczema (atopic dermatitis), ATOPIC DERMATITIS, dermatitis, atopic, Dermatitis, hand dermatitis, Asthma, Asthma, Asthma (Pediatric), Allergies & Asthma, Asthma (Pediatric), Allergies & Asthma, Https://Meshb.Nlm.Nih.Gov/Record/ui?ui=D003876, Atopic Dermatitis and Related Conditions, dermatitis, atopic
Age	1years - 100years
Clinical Study Identifier	NCT04240522
Sponsor	University of Zurich
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	\-
	The inclusion criteria for patients in this study are as follows
	Age 0 - 85 years
	Diagnosis of AD and/or another disease of the atopic group (i.e. allergic rhinitis, allergic asthma, food allergy)
	The inclusion of patients in this study is independent from the current therapy. During the study all patients will be kept on a therapy that is medically indicated
	The inclusion criteria for healthy controls in this study are as follows
	Age 0 - 85 years
	No diagnosis or history of allergic disease
	The inclusion of patients in this study is independent from the current therapy. During the study all patients will be kept on a therapy that is medically indicated Written consent will be obtained after detailed information of the study was given to the participant
	Exclusion Criteria Unable to give consent or refusal to participate in the
	study

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Prospective Longitudinal Observational Research in Atopic Dermatitis