An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

  • STATUS
    Recruiting
  • participants needed
    250
  • sponsor
    Genentech, Inc.
Updated on 19 February 2024
cancer
serum pregnancy test
measurable disease
atezolizumab
solid tumour
solid tumor
anticoagulants
solid neoplasm

Summary

This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 alone or in combination with a checkpoint inhibitor treatment in participants with locally advanced or metastatic solid tumors.

Details
Condition Solid Tumors
Age 18years - 100years
Treatment Atezolizumab, XmAb24306
Clinical Study IdentifierNCT04250155
SponsorGenentech, Inc.
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
Life expectancy >/= 12 weeks
Adequate hematologic and end-organ function
For participants receiving therapeutic anticoagulation: stable anticoagulant regimen
Negative serum pregnancy test for women of childbearing potential
Histologically confirmed locally advanced, recurrent, or metastatic incurable solid tumor malignancy
Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
Availability of representative tumor specimens

Exclusion Criteria

Pregnant or breastfeeding, or intending to become pregnant during the study
Significant cardiovascular disease
Current treatment with medications that prolong the QT interval
Known clinically significant liver disease
Poorly controlled Type 2 diabetes mellitus
Symptomatic, untreated, or actively progressing CNS metastases
History of leptomeningeal disease
History of malignancy other than disease under study within 3 years prior to screening
Active or history of autoimmune disease or immune deficiency
Active tuberculosis, hepatitis B, hepatitis C, or known/suspected Epstein Barr virus infection
Positive for HIV infection
Prior allogeneic stem cell or solid organ transplantation
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