Sleep-disordered Breathing in Infants With Myelomeningocele
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- STATUS
- Recruiting
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- days left to enroll
- 74
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- participants needed
- 173
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- sponsor
- University of Michigan
Summary
This study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs. postnatal surgery, and to examine the link between sleep-disordered breathing and neurodevelopment.
Description
Myelomeningocele (MMC), the most severe form of spina bifida, is characterized by exposure of the spinal cord through a spinal defect. Sleep-disordered breathing (SDB) is common in children with MMC and is a risk factor for sudden death. Abnormal sleep physiology is likely multifactorial, related to MMC level, brainstem dysfunction, musculoskeletal factors, and pulmonary abnormalities. In infants, SDB may be treatable with oxygen, caffeine, or positive airway pressure. Yet, SDB screening is not routine, even in centers with specialized MMC programs.
Evaluation of sleep in neonates who require intensive care is an emerging opportunity with potential for major impact on health and quality of life for affected children. As SDB and abnormal sleep are potentially treatable, early assessment and intervention could become an integral part of a multidisciplinary treatment strategy to optimize long-term medical and neurodevelopmental outcomes.
Details
| Condition | Meningomyelocele, Sleep apnea |
|---|---|
| Age | 2 years and younger |
| Treatment | neonatal polysomnography, 2-year Bayley Exam, 2-year polysomnography |
| Clinical Study Identifier | NCT04251806 |
| Sponsor | University of Michigan |
| Last Modified on | 19 February 2024 |
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