Measles Vaccination at Health System Contacts

  • STATUS
    Recruiting
  • participants needed
    5400
  • sponsor
    Bandim Health Project
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Updated on 19 February 2024
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vaccination
measles

Summary

In addition to protecting against measles infection, measles vaccine (MV) strengthens the individual's ability to combat infections in general - MV has beneficial non-specific effects (NSE) lowering the risk of death and admissions by around 30%.

In Guinea-Bissau 30% of children do not receive a routine MV scheduled at 9 months of age, putting both the individual child's health and measles eradication at risk. WHO recommends vaccination at health system contacts, including those for curative services. At the paediatric ward of the national hospital in Guinea-Bissau, there are more than 2600 yearly contacts with measles-unvaccinated children aged 9-59 months, but no vaccines are given. In a randomised controlled trial, we will assess the effect of providing MV vs placebo to 5400 children at hospital contacts (at discharge or after an out-patient consultation) to test the hypothesis that MV reduces the risk of admission or death (composite outcome) by 25% over the subsequent 6 months.

Details
Condition Aspects of mortality statistics, Measles Vaccine, Mortality, Hospital Admission, Non-specific (Heterologous) Effects of Vaccines
Age 1years - 1years
Treatment Saline, measles vaccine
Clinical Study IdentifierNCT04220671
SponsorBandim Health Project
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Measles-unvaccinated children
-59 months with a hospital contact (discharged or outpatient consultation) at the paediatric ward at the national hospital Simao Mendes

Exclusion Criteria

Axil temperature >38.0
Mid upper arm circumference <110 mm
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