IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas

  • STATUS
    Recruiting
  • End date
    Jun 28, 2026
  • participants needed
    150
  • sponsor
    Gustave Roussy, Cancer Campus, Grand Paris
Updated on 19 February 2024
squamous cell carcinoma
carcinoma

Summary

Compare patients' feelings in terms of swallowing ability assessed by the overall score of MD Anderson Dysphagia Inventory (MDADI) 2 years after starting treatment between patients who have been treated with IMRT and those who were treated by transoral surgery for a squamous cell carcinoma of the early stage oropharynx.

Details
Condition Carcinoma, Squamous cell carcinoma, Squamous cell carcinoma
Age 18years - 100years
Treatment transoral resection, IMRT
Clinical Study IdentifierNCT04224389
SponsorGustave Roussy, Cancer Campus, Grand Paris
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years old
ECOG performance status 0-2
Histologically confirmed squamous cell carcinoma
Primitive localization of the oropharynx on the tonsil compartment or the tongue base
p16 or HPV status available
TNM classification AJCC7th T1 or T2
TNM classification AJCC7th N0 or N1
Patient and tumor that can be treated by radiotherapy or by transoral surgery
Patient who has not objected to participate after being informed about the study. The patient must be able and willing to cooperate in follow-up and study visits

Exclusion Criteria

Severe medical comorbidity or other contraindication to radiotherapy or surgery
Primary tumor or unresectable lymphadenopathy
Metastatic disease
History of squamous cell carcinoma of the head and neck within 5 years
History of radiation therapy to the head and neck
Inability to undergo or complete radiation therapy follow-up consultations
History of cancer except free of any disease for at least 5 years, with the exception of non-melanoma skin cancers
Inability to complete questionnaires
Pregnant or lactating woman
Patient under tutorship or curatorship, deprived of liberty or unable to do so to express consent
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