IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas

  • STATUS
    Recruiting
  • End date
    Jun 28, 2026
  • participants needed
    150
  • sponsor
    Gustave Roussy, Cancer Campus, Grand Paris
Updated on 19 February 2024
squamous cell carcinoma
carcinoma

Summary

Compare patients' feelings in terms of swallowing ability assessed by the overall score of MD Anderson Dysphagia Inventory (MDADI) 2 years after starting treatment between patients who have been treated with IMRT and those who were treated by transoral surgery for a squamous cell carcinoma of the early stage oropharynx.

Details
Condition Carcinoma, Squamous cell carcinoma, Squamous cell carcinoma
Age 18-100 years
Treatment transoral resection, IMRT
Clinical Study IdentifierNCT04224389
SponsorGustave Roussy, Cancer Campus, Grand Paris
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years old
ECOG performance status 0-2
Histologically confirmed squamous cell carcinoma
Primitive localization of the oropharynx on the tonsil compartment or the tongue base
p16 or HPV status available
TNM classification AJCC7th T1 or T2
TNM classification AJCC7th N0 or N1
Patient and tumor that can be treated by radiotherapy or by transoral surgery
Patient who has not objected to participate after being informed about the study. The patient must be able and willing to cooperate in follow-up and study visits

Exclusion Criteria

Severe medical comorbidity or other contraindication to radiotherapy or surgery
Primary tumor or unresectable lymphadenopathy
Metastatic disease
History of squamous cell carcinoma of the head and neck within 5 years
History of radiation therapy to the head and neck
Inability to undergo or complete radiation therapy follow-up consultations
History of cancer except free of any disease for at least 5 years, with the exception of non-melanoma skin cancers
Inability to complete questionnaires
Pregnant or lactating woman
Patient under tutorship or curatorship, deprived of liberty or unable to do so to express consent
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.