FDG PET-MRI for the Diagnosis of Spinal Cord Lesions

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    M.D. Anderson Cancer Center
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Updated on 19 February 2024
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spinal cord
positron emission tomography

Summary

This trial studies the best time point of using F18-FDG that gives the best image on PET-MRI in patients with spinal cord lesions of unknown cause. Diagnostic procedures, such as F18-FDG PET-MRI, may help find and diagnose spinal cord lesions.

Description

PRIMARY OBJECTIVES:

I. To identify the optimal imaging time point using fludeoxyglucose F-18 (F18-FDG) positron emission tomography (PET) that gives the best lesion conspicuity as defined by the best lesion to background (L/B) ratio when evaluating spinal cord lesions of unknown etiology.

EXPLORATORY OBJECTIVES:

I. To identify malignancy specific factors in F18-FDG metabolism derived from metrics such as maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), total lesion glycolysis (TLG), metabolic tumor volume (MTV) and L/B ratio.

OUTLINE

Patients receive fludeoxyglucose F-18 intravenously (IV) over 1 minutes and then undergo PET-magnetic resonance imaging (MRI) over 15-60 minutes at 60, 300, and 480 minutes after fludeoxyglucose F-18 injection in the absence of unacceptable toxicity.

Details
Condition Myelopathy, Benign neoplasm of spinal cord
Age 18years - 100years
Treatment Fludeoxyglucose F-18, Magnetic Resonance Imaging, Positron Emission Tomography
Clinical Study IdentifierNCT04219969
SponsorM.D. Anderson Cancer Center
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients with untreated intramedullary cord lesion(s)
Ability to undergo FDG PET MR examination

Exclusion Criteria

No prior surgery or biopsy of the spinal cord
No metal implanted in area of interest
Spine radiation therapy
Known allergy to FDG or gadolinium based contrast agents
Blood glucose (> 200 mg/dl)
Pregnant women are excluded
Need for conscious sedation or anesthesia in order to tolerate study
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