Study of DC-CIK Combined With Chemotherapy for Advanced Solid Tumor

STATUS

Recruiting
participants needed

60
sponsor

Yantai Yuhuangding Hospital

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Updated on 19 February 2024

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psychiatric disorder

cancer

platelet count

metastasis

solid tumor

brain metastases

advanced solid tumor

advanced malignant solid tumor

Summary

Combinations of Dendritic cell-activated cytokine-induced killer cell (DC-CIK) With chemotherapy treatment may enhance the immune response and stop cancer cells from growing.

Description

Patients in group A will receive 4 cycles of DC-CIK treatments within 8 months. Patients in group B will have no immunotherapy. Chemotherapy are available in both groups.The investigators want to evaluate the efficacy of combination of DC-CIK with chemotherapy in patients with treatment-refractory solid tumors.

Details

Condition	Solid Tumor
Age	10years - 90years
Treatment	DC-CIK combined with Chemotherapy, Chemotherapy
Clinical Study Identifier	NCT04214717
Sponsor	Yantai Yuhuangding Hospital
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Patients with treatment-refractory advanced solid cancer can not accept operation
	Age 18 to 75 years
	Eastern Cooperative Oncology Group (ECOG) score 2 points
	estimate survival > 3 months
	Blood White Blood Cell(WBC) 4109/L, Hb 100g/L, Platelet Count (PLT) 80109/L; Alanine amino transferase (ALT) and aspartate amino transferase (AST) 2 times of normal upper value; Serum Cr 2 normal upper value
	Without any other malignant disease
	With more than one scalable lesions
	Patients Voluntary attempt, and informed consent
	Women of child-bearing potential must have a negative pregnancy test because of the potentially dangerous effects of the preparative chemotherapy on the fetus
Exclusion Criteria
	Patients who do not conform to the inclusion criteria
	Patients with uncontrolled infection; underlying disease that was severe or life-threatening (such as uncontrolled brain metastasis )
	Patients who were pregnant or lactating
	ECOG perform status 2;4
	Other situations that the researchers considered unsuitable for this study (such as mental illness, drug abuse, etc.)

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Study of DC-CIK Combined With Chemotherapy for Advanced Solid Tumor