EsophaCap for the Detection of Early Esophageal Carcinoma

  • STATUS
    Recruiting
  • End date
    Dec 19, 2025
  • participants needed
    2500
  • sponsor
    Johns Hopkins University
Updated on 19 February 2024
cancer
squamous cell carcinoma
adenocarcinoma
early diagnosis
carcinoma
gastric cancer
esophageal carcinoma
barrett's esophagus
esophagogastroduodenoscopy
early detection

Summary

This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma), and gastric cancer via sponge cytology.

Description

This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma). Esophageal and gastric cytology will be collected via sponge capsule. Candidate genes will be tested with DNA isolated from these samples in order to identify optimal biomarkers to differentiate between Barrett's esophagus and esophageal/gastric cancer versus normal esophageal/gastric tissue.

Details
Condition Esophageal Diseases, Esophageal Cancer, Esophageal Cancer, Precancerous Conditions, Gastropathy, Gastric Cancer, Gastric Cancer, head and neck cancer, head and neck cancer, BARRETT'S ESOPHAGUS, BARRETT'S ESOPHAGUS
Age 18-100 years
Clinical Study IdentifierNCT04214119
SponsorJohns Hopkins University
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Undergoing esophagogastroduodenoscopy at Johns Hopkins Hospital from 1/2016 to 12/2025
Age greater than 18 years
Patients must be able to swallow a capsule

Exclusion Criteria

Patients in either arm with extra-esophageal malignancies including head and neck and gastric cancer
Patients who have undergone esophagectomy
Patients who have undergone radiation to the chest
Patients who are younger than 18
Patients with esophageal stents
Patients with esophageal strictures disabling passage of the capsule
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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