Childhood Allergy and the Neonatal Environment

  • STATUS
    Recruiting
  • participants needed
    500
  • sponsor
    University of Wisconsin, Madison
Updated on 19 February 2024
rhinitis
hay fever
asthma
allergic rhinitis
pollen allergy

Summary

The purpose of this research study is to study the relationship between childhood asthma, allergies, and early-life environmental factors that may cause childhood asthma and allergies. Previous birth cohort studies have found early-life environmental factors such as allergies, pollutants, viruses and bacteria have all contributed to the development of asthma and allergies. Investigators are doing this research because there continues to be a strong need to understand the root causes of asthma and allergies. The CANOE study is an observational cohort study, which means investigators are not asking participants or participant's child to change their medications and investigators will not be giving participants or participant's child a study drug.

Description

The CANOE study will provide an opportunity to collect novel longitudinal samples not available from the current CANOE birth cohorts, as well as enhanced and standardized environmental sampling in early life. One of the main goals of this study is to gather data and specimens, beginning in the prenatal periods, that will assess environmental exposures to toxins and microbes, and host characteristics including genetics, epigenetics, gene expression, the proteome and metabolome, microbial colonization and viral respiratory infections. The main study outcomes will be important interim conditions (e.g., recurrent wheeze, early multiple sensitization) that are highly associated with the development of asthma. Additional outcomes (perinatal outcomes, growth, neurocognitive development) will be collected as part of the collaborative Environmental Influences on Child Health Outcomes (ECHO)-wide Cohort Data Collection Protocol.

Details
Condition Immunology, Hypersensitivity, Asthma in Children
Age 100years or below
Clinical Study IdentifierNCT04215783
SponsorUniversity of Wisconsin, Madison
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Planning to deliver at the study hospital
History of or concurrent asthma or allergic rhinitis (hay fever) in either biologic parent or sibling (at least one shared biological parent) by parental report. The presence of paternal or sibling allergy or asthma will be ascertained by maternal report
Maternal age > 18 years at the time of study enrollment

Exclusion Criteria

Maternal HIV infection at time of delivery
Plans for the family to move out of the geographic area during the period of the study
Does not speak English
Maternal use of progesterone during pregnancy to prevent preterm birth
Past or current medical problems or findings from physical examination or laboratory testing which, in the opinion of the investigator or designee, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study
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