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A Study of the Pharmacokinetics, Biodistribution and Dosimetry of Granzyme-B Targeted [Cu-64]-Labeled PET Radiotracers in Adult Healthy Volunteers

Study on how Granzyme-B PET tracers move in healthy adults.

Recruiting
18-60 years
All
Phase 0

This study is for adults aged 18-60 who are healthy and want to help researchers learn more about how a special compound, called GzmB-targeted [Cu-64]-labeled compound, moves and acts in the body. This compound is used in PET/CT scans, a type of imaging that helps doctors see inside the body. The study involves getting one injection, several scans and tests over 24 hours, and a follow-up phone call a week later.

To join, you must be healthy, not pregnant or breastfeeding, and able to have scans and tests. You should also not have any infections or serious illnesses, and must not have had major surgery recently. You will need to agree to use birth control if you are of childbearing potential or have a partner who is.

  • The study lasts about 24 hours, with a follow-up call at Day 7.
  • Participants will undergo multiple PET/CT scans and tests.
  • Up to 12 healthy volunteers will take part.
Study details
    Healthy Volunteer

NCT07774650

Ratio Therapeutics, Inc.

20 August 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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