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Efficacy of an Anti-TSLP Monoclonal Antibody in the Management of Chronic Bronchial Disease Induced by Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Stem Cells Transplantation Recipients

Testing new antibody treatment for lung disease in transplant patients.

Recruiting
18 years and older
All
Phase 2

This study is for adults aged 18 and older who have had a special kind of stem cell transplant over 3 years ago. It's looking at how well an investigational medication works for people with breathing problems called Bronchiolitis Obliterans Syndrome (BOS). This happens when small airways in the lungs get blocked, making it hard to breathe.

The study tests if the investigational medication can reduce lung flare-ups for people who already use inhalers and medicine to control their breathing. Participants should have had 2 or more flare-ups in the past year and be on a stable dose of certain medications.

  • Time Commitment: Multiple visits over a period to monitor progress.
  • Eligibility: Participants need to be stable on their current medications and have no recent lung infections.
  • Risks: People who are allergic to the investigational medication or have certain health conditions cannot participate.

Participants must sign a consent form and have health insurance. Women who are pregnant or breastfeeding can't join the study. If interested, consider discussing with your doctor. 🩺

Study details
    Bronchiolitis Obliterans Syndrome (BOS)
    HSCT
    Bronchial Disease

NCT07771855

Hopital Foch

19 August 2026

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