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Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer

Trying new treatment with SHR-1701 and chemoradiotherapy for rectal cancer.

Recruiting
18-75 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This clinical trial is studying a combination of treatments for locally advanced rectal cancer (a type of cancer affecting the lower part of the large intestine). Participants will receive an investigational medication along with chemotherapy and radiation therapy to see if this combination helps treat the cancer better. Chemotherapy involves drugs that kill cancer cells, and radiation therapy uses high-energy rays to target and shrink tumors.

Participants will go through three phases: Induction (1 cycle of 21 days), Radiotherapy (5 consecutive days), and Consolidation (5 cycles of 21 days each), followed by surgery within 4 to 8 weeks.

  • **Study Length**: Around 6 months including follow-up before surgery.
  • **Visits Needed**: Multiple visits over the study for treatments and monitoring.
  • **Eligibility**: Ages 18-75, diagnosed with rectal cancer, must not have had prior cancer treatment.

If you are between 18 and 75 and have locally advanced rectal cancer, you may qualify. You cannot have allergies to certain drugs or have had specific treatments before. Consider whether the time commitment and treatment phases align with your schedule and health needs.

Study details
    CRC (Colorectal Cancer)

NCT07478731

Hong Qiu

19 March 2026

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