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Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer

Explore SHR-1701 with chemoradiotherapy for advanced rectal cancer.

Recruiting
18-75 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Study Purpose: This clinical trial is researching if an investigational medication combined with chemoradiotherapy can help treat severe rectal cancer, a type of cancer that affects the last part of the large intestine.

Participation Details:

  • Time Commitment: The study consists of several phases over approximately 9 months, including surgery.
  • Visits Needed: Regular visits for treatment administration and monitoring.
  • Eligibility: Adults aged 18-75 with specific types of rectal cancer who have not had prior cancer treatments. Participants must be able to swallow pills and meet health criteria.

Key Medical Terms:

  • Chemoradiotherapy: Treatment that combines chemotherapy (cancer-fighting drugs) and radiotherapy (radiation to kill cancer cells).
  • TME Surgery: A procedure to remove rectal cancer.
  • CAPOX Regimen: A combination of two chemotherapy drugs: Capecitabine and Oxaliplatin.

Before joining, participants will sign an informed consent form to ensure they understand the study. Eligibility includes certain medical conditions and health assessments. Exclusion criteria include allergies to study medications and certain health conditions.

Study details
    CRC (Colorectal Cancer)

NCT07478731

Hong Qiu

19 March 2026

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