Adaptive Radiotherapy for Genitourinary Cancers

  • STATUS
    Recruiting
  • End date
    Dec 31, 2028
  • participants needed
    60
  • sponsor
    Cancer Institute and Hospital, Chinese Academy of Medical Sciences
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Updated on 8 January 2026
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Summary

The goal of this clinical trial is to learn if adaptive radiation boost works to treat genitourinary cancers, esp. in the context of prostate cancer patients with post-prostatectomy local relapse and bladder cancer patients with bladder-conserving treatment. It will also learn about the safety and efficacy of adaptive boost. The main questions it aims to answer are:

Does adaptive boost lower the toxicities? Does adaptive boost maintain or improve the clinical efficacy?

Participants will:

Undergo adaptive boost on 1.5-Tesla MR-Linac Visit the clinic once every 2 weeks during RT, and every 3 months post-ART Keep a regular QOL questinnaire completion

Details
Condition Prostate Cancer (Post Prostatectomy), Bladder Cancer
Age 18years or above
Clinical Study IdentifierNCT07324798
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences
Last Modified on8 January 2026

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients with newly diagnosed or metastatic/recurrent pathologically confirmed urological tumors, clinically assessed as suitable for adaptive radiotherapy
Age ≥ 18 years
ECOG performance status score 0-2
No prior radiotherapy history within the current radiation field
No contraindications for MRI scanning
No contraindications for radiotherapy

Exclusion Criteria

Patients with contraindications to radiotherapy
Patients unable to tolerate MRI or with contraindications to MRI scanning
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