Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer (PSOAS)

  • STATUS
    Recruiting
  • End date
    May 24, 2028
  • participants needed
    158
  • sponsor
    University Hospital, Lille
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Updated on 24 November 2025
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Summary

Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation. However, the rehabilitation concept does not allow to improve muscular and functional reserves at the time of surgery. Sarcopenia is a condition characterized by loss of skeletal muscle mass and function. Also, the prevalence of sarcopenia in patients with cancer is high and has a prevalence of around 25% in patients with pancreatic cancer, with a considerable impact on postoperative and survival outcomes.

The hypothesis is the preoperative management of sarcopenia by a rehabilitation program could improve patients' operative outcomes by reducing the rate of postoperative complications.

Details
Condition Sarcopenia, Pancreatic Cancer
Age 18years or above
Clinical Study IdentifierNCT04469504
SponsorUniversity Hospital, Lille
Last Modified on24 November 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients undergoing pancreaticoduodenectomy for cancer
Sarcopenic status

Exclusion Criteria

Age younger than 18 years
Medical contraindications including cardiovascular disease or clinically significant vascular disease
Physical inability to exercise
Emergent surgery
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