This study investigates the impact of environmental pollutants on neurological disorders such as brain tumors and cerebrovascular diseases. Environmental pollutants, including heavy metals like lead and mercury, as well as novel pollutants like microplastics and per- and polyfluoroalkyl substances (PFAS), can cross the blood-brain barrier and accumulate in neural tissue. This accumulation can lead to oxidative stress, inflammation, and other changes that affect brain health.
The study will involve analyzing various biospecimens such as blood, urine, hair, and tumor tissues to profile pollutant exposure. This will help explore how these pollutants contribute to the development and progression of brain tumors and cerebrovascular diseases. Understanding these mechanisms may help identify biomarkers for assessing disease risk and guiding prevention strategies.
- Who can participate: Participants must be 18 years or older and able to provide informed consent. Pregnant or breastfeeding women are not eligible.
- Study details: Participants will provide biospecimens such as blood, urine, hair, and tissue samples for analysis. This will help in profiling exposure to various pollutants and understanding their impact on neurological disorders.