Study Purpose: This research is looking into how the common cold virus affects people with bronchiectasis, a lung condition. It will see if it causes flare-ups and how the immune system responds compared to healthy individuals.

Eligibility: Adults aged 18 to 65 can join. We need people with bronchiectasis and healthy individuals. If you have any major health issues, are pregnant, or smoke, you might not be eligible.

Study Details: The study lasts 42 days (about 6 weeks). Participants will get a spray containing a cold virus in their nose. There will be a total of 11 visits, with some tests like blood tests, lung checks, and bronchoscopy (a test that checks inside your lungs). You'll need to keep a daily record of your symptoms.

• Length of Study: 42 days with 11 visits.
• Participation: Sprayed with a cold virus and monitored closely.
• Exclusion: No smoking, pregnancy, or recent use of certain medications.

Note: This research takes place at St Mary's Hospital in London, UK.