This study investigates the relationship between thrombocytopenia and symptoms such as fatigue and cognitive disorders. Thrombocytopenia is a condition where there is a lower than normal number of platelets in the blood, which can lead to excessive bleeding. It can be caused by reduced production of platelets in the bone marrow, increased destruction of platelets, or increased sequestration in the spleen. In some cases, thrombocytopenia may also be associated with cognitive disorders, though the exact mechanism is not well understood.

Participants in the study will undergo procedures to assess their platelet levels and symptoms of fatigue and cognitive function. The study will include questionnaires to detect cognitive disorders. The hypothesis is that the decrease in circulating neurotrophic factor levels due to reduced secretion from platelet granules may explain the fatigue experienced by patients with thrombocytopenia.

• Who can participate: Adults or minors with diagnosed thrombocytopenia, either constitutional or autoimmune, who are not receiving SSRIs, SNRIs, or antithrombotic medications are eligible. Healthy adult volunteers matched by age and sex, not on certain medications, can also participate.
• Study details: Participants will consent after receiving a detailed explanation of the research. The study involves monitoring platelet levels and assessing symptoms of fatigue and cognitive function. A placebo is not involved.