This study investigates the role of specific cytokines in periodontal disease, which is a condition characterized by microbial infections and inflammation of the tissues supporting the teeth. Periodontal disease can lead to the destruction of tissues and bone loss around the teeth. Gingivitis is a mild form of periodontal disease caused by bacterial plaque, and if untreated, it can progress to periodontitis, which is the main cause of tooth loss in adults. The study focuses on cytokines such as GM-CSF, MIP-1α, and IL-1β, which are involved in inflammation and immune responses, to understand their potential role in the progression of periodontal disease.

Participants in this study will provide saliva samples to measure the levels of GM-CSF, MIP-1α, and IL-1β. These cytokines are known to play roles in inflammation and immune response. GM-CSF is involved in the formation of immune cells, MIP-1α attracts immune cells to sites of inflammation, and IL-1β is a key player in immune response regulation. By examining these cytokines, the study aims to assess their potential as diagnostic markers for periodontal disease and explore pathways for future treatments.

• Who can participate: Adults who are systemically healthy, have at least twenty permanent teeth, do not smoke, and are not on continuous medication can participate. Pregnant or breastfeeding individuals are excluded.
• Study details: Participants will provide saliva samples to measure cytokines involved in inflammation, including GM-CSF, MIP-1α, and IL-1β. No placebo is involved in this study.