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Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)

Studying How Diet Affects Thinking and Heart Health

Recruiting
45-64 years
All
Phase N/A

This study investigates the relationship between a healthy diet, thinking ability, and heart health. Participants will consume either a microwaveable study meal or a prepackaged smoothie every day for 12 weeks. These meals, delivered by a meal service, follow dietary patterns that are thought to improve brain and heart health, known as the MIND diet, or a control diet. The MIND diet includes foods commonly found in grocery stores and is believed to benefit cognitive and cardiovascular health.

Participants will attend four in-person laboratory visits to complete several computer-based tests of memory and attention while wearing an EEG cap, which measures brain activity. They will also complete an eye test, heart rate and blood pressure assessments, a bone and body scan called DXA, and a blood draw at the beginning and end of the study. Additionally, participants will fill out online forms or surveys to provide more information about their health and dietary habits.

  • Who can participate: Adults aged 45 to 64 years with normal or corrected vision, no food allergies, and no recent pregnancy or certain medical conditions can participate.
  • Study details: Participants will consume meals that follow either the MIND diet or a control diet, without knowing which one they are assigned to. They will follow dietary guidance and complete health assessments and cognitive tests.
  • Study Timelines and Visits: The study will last 12 weeks. The study requires 4 visits.
Study details
    Cognitive Change
    Diet
    Healthy
    Metabolic Syndrome
    Protection Against

NCT06605898

University of Illinois at Urbana-Champaign

18 May 2025

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