Purpose: This study will look at why babies and children have high ammonia levels in their blood and how it affects them. Ammonia is a waste product that the body makes when it breaks down protein. If it's too high, it can cause problems like irritability, vomiting, or more serious issues like seizures.
Participants: We are looking for newborns, infants, and children with high ammonia levels. This includes babies with unexplained symptoms like seizures, weak muscles (hypotonia), ongoing jaundice, metabolic issues, or strange-smelling urine. Children with high ammonia levels can also join. Those with high ammonia due to non-metabolic reasons, like liver disease, cannot join.
Study Details: The study will take place at Assiut University Hospital's Pediatric Genetic unit. The study will focus on identifying the causes of high ammonia levels and how they present in children.
- **Length of Study & Visits:** The duration and number of visits will be discussed during enrollment.
- **No investigational medication will be given.**
- **No compensation is provided.**