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Study of Lademirsen (SAR339375) in Patients With Alport Syndrome

Testing a new tool for managing children's allergy symptoms.

Recruiting
18-55 years
All
Phase 2

This study is for people with Alport Syndrome, a genetic condition affecting the kidneys, ears, and eyes. The research aims to see if an investigational medication can help slow kidney damage and is safe for patients. Participants will join for about 110 weeks, almost two years. This time includes a four-week screening, 48 weeks with either the medication or a placebo (a pill with no effect), another 48 weeks with the actual medication, and a 10-week follow-up.

To be eligible, you need to:

  • Be between 18-55 years old with a confirmed diagnosis of Alport Syndrome.
  • Have kidney function within a specific range (eGFR between 35 and 90), a measure of how well your kidneys work.
  • Not have other major kidney diseases or conditions affecting drug absorption.

Participants must agree to certain lifestyle rules, like using birth control if applicable. This study requires several visits to the clinic, and you should be comfortable with this commitment.

Study details
    Alport's Syndrome
    Acne

NCT02855268

Genzyme, a Sanofi Company

1 December 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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