Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm
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- STATUS
- Recruiting
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- participants needed
- 30
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- sponsor
- Nicolaas Bohnen, MD, PhD
Summary
The arm of this study evaluates possible GABA-A receptor target engagement effects of the FDA-approved medication, transdermal flumazenil (added 4/2020, replaced clarithromycin), in the setting of Parkinson's disease. Half of the subjects will receive transdermal flumazenil for 7-10 days, and half will receive a placebo. [11C]Flumazenil GABA-A receptor PET imaging will be used to assess target engagement effects.
Description
This study focuses on neurochemical changes in the brain that occur in Parkinson's disease. In particular we will be looking a neurotransmitter called GABA. In some Parkinson's disease patients we see too much GABA activity in the brain. This target engagement study examines the target engagement effect of GABA-A receptor modulation by transdermal flumazenil (previously clarithromycin). [11C]-flumazenil Positron Emission Tomography (PET) imaging results will be used to assess for possible GABA-A receptor target engagement effects of transdermal flumazenil (previously clarithromycin).
Details
| Condition | Parkinson's Disease, Parkinson's Disease |
|---|---|
| Age | 50years - 100years |
| Treatment | Clarithromycin (Not used as of 4/2020), Placebo (Not used as of 4/2020), Transdermal flumazenil (Added 4/2020), Placebo (Added 4/2020) |
| Clinical Study Identifier | NCT03440112 |
| Sponsor | Nicolaas Bohnen, MD, PhD |
| Last Modified on | 19 February 2024 |
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