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Assessment of LET-Based Models and Changes Seen on Brain Imaging in Pediatric Patients Following Proton Therapy for Primary Central Nervous System or Base of Skull Tumors

Assessment of LET-Based Models and Changes Seen on Brain Imaging in Pediatric Patients Following Proton Therapy for Primary Central Nervous System or Base of Skull Tumors

Recruiting
3-21 years
All
Phase N/A

Overview

This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time. This study may help providers learn more about proton beam radiotherapy and how to improve the way it is delivered.

Description

PRIMARY OBJECTIVE:

I. To establish linear energy transfer (LET)-based models as early predictors for white matter changes on magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) sequences in pediatric patients following proton beam therapy for primary central nervous system (CNS) and base of skull tumors.

OUTLINE

Patients' medical charts are reviewed.

Eligibility

Inclusion Criteria:

  • Patients must have histologically confirmed central nervous system of skull base tumors
  • Patient is going to undergo central nervous system (CNS) or base of skull proton beam therapy

Exclusion Criteria:

  • Patients who have received prior therapeutic radiotherapy
  • Patients who are unable to maintain follow-up through the Phoenix Children's Hospital and Mayo Clinic Arizona

Study details
    Malignant Central Nervous System Neoplasm
    Malignant Skull Base Neoplasm

NCT04296617

Mayo Clinic

19 February 2024

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