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Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery

Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery

Recruiting
18-95 years
All
Phase N/A

Overview

  1. Access the optimal cut point value of copeptin which predicts development of central diabetes insipidus postoperatively with highest accuracy.
  2. Access the optimal cut point value of copeptin which predicts the lack of central diabetes insipidus postoperatively with highest accuracy
  3. Access the relative change in copeptin values between baseline and post-surgery as a predictor for diabetes insipidus development.

Description

Patient serum levels of copeptin would be measured after phlebotomy of 3 ml of blood in EDTA tube twice a) within 1-4 hours of extubation and b) within 4-24 hours of extubation (the morning following surgery).

Eligibility

Inclusion Criteria:

  • Patients with sellar and suprasellar masses who undergo neurosurgical procedure at Mayo Clinic Rochester.

Exclusion Criteria:

  • Patients with preexisting CDI.

Study details
    Pituitary Adenoma
    pituitary tumor
    Sellar and Suprasellar Masses

NCT04369703

Mayo Clinic

19 February 2024

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