One-Year Quality of Life and Functional Prognosis of COVID-19 Patients in Post-ICU Setting

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50
sponsor

Groupe Hospitalier Paris Saint Joseph

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Updated on 19 February 2024

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pulmonary function tests

atrophy

weakness

covid-19

respiratory failure

lung ultrasound

lung function

Summary

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The COVID-19 disease has been subject to numerous publications since its emergence. Almost 20% of people suffering from COVID-19 develop severe to critical symptoms and require hospitalization, often in Intensive Care Unit (ICU). Respiratory failure is the main reason for admission in ICU of these patients. Therapeutic strategies implemented for the management of critically-ill patients may often lead to short-term muscular and functional alterations resulting in ICU-Acquired Weakness (ICUAW). These lead to long-term disabilities expressing trough dependence and quality of life impairment of survivors.

The purpose of this study is to assess the quality of life, dependence and survival at one year in patients who survived from COVID-19 in ICU and are admitted in post-ICU setting for difficult weaning purpose.

Ancillary studies aim to assess the course of muscle function (atrophy, structural modifications), lung function (loss of aeration) and safety of early mobilization.

Description

SARS-Cov-2, a virus causing a new infectious disease called COVID-19, has been subject to numerous publications since its emergence. Almost 20% of people infected with SARS-Cov-2 develop severe to critical symptoms and required hospitalization, often in Intensive Care Unit (ICU).

Respiratory failure is the main reason for admission in ICU of patients with COVID-19, which develop an Acute Respiratory Distress Syndrome (ARDS). Respiratory failure may be associated to liver, renal, coagulation and hemodynamic failure.

Therapeutic strategies implemented for the management of critically-ill patients with COVID-19 may often lead to short-term muscular and functional alterations resulting in ICU-Acquired Weakness (ICUAW), as studied in other ICU population.

The muscular and functional impairments of patients are associated to a longer duration of mechanical ventilation and hospital length of stay and increased mortality. Long-term impacts are also reported like dependence and quality of life impairment of survivors.

The COVID-19 pandemic currently leads to an increasing number of ICU admission in France with a high risk of settings saturation. Specialized settings for post-ICU rehabilitation are preparing to early receive difficult-to-wean patients with ICUAW after admission in ICU for severe or critical form of COVID-19.

To our best knowledge, no data is obviously available regarding at the future of these patients in terms of quality of life, dependence or survival. Moreover, no short-term data are available concerning the course of lung damages and muscle function after ICU stay. The safety of early mobilization usually delivered in patients admitted to post-ICU settings has never been assessed in patients with COVID-19.

Ancillary studies aim to assess course of muscle function (atrophy, structure modification), lung function (loss of aeration) and safety of early mobilization.

Details

Condition	Covid 19, ICU Acquired Weakness, Weaning Failure
Age	18years - 100years
Treatment	lung ultrasound, Muscle ultrasound
Clinical Study Identifier	NCT04373811
Sponsor	Groupe Hospitalier Paris Saint Joseph
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Patient initially hospitalized in ICU for COVID-19
	Admitted in post-ICU setting (difficult-to-wean unit)
	Age > 18 years old
	Membership of a social insurance sheme
	Medical prescription of early mobilization
	Patient or relative provides consent
Exclusion Criteria
	Known pregnancy
	Person subject to judicial health protection
	Patient under legal guardianship or curatorship
	Contraidication for early mobilization
	Decision to withhold lifesustaining treatment

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One-Year Quality of Life and Functional Prognosis of COVID-19 Patients in Post-ICU Setting