Prognostic Factors of COVID19
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- STATUS
- Recruiting
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- participants needed
- 500
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- sponsor
- University Hospital, Strasbourg, France
Summary
COVID-19 is an emerging disease, for which no specific treatment options are currently available. Since the end of February 2020, and due to a SARS-CoV-2 superspreading event (religious meeting), the Strasbourg University Hospital (HUS) had faced a sudden increase of the number of COVID-19-positive patients in serious condition requiring hospitalization. At the same time, many people develop only mild or moderate symptoms. To date, the prognostic factors for the course of SARS-CoV-2 infection are unknown. The primary purpose of the "COVID-HUS" protocol is to investigate viral and host-related factors to understand the pathophysiology of COVID infection and to open the way for new diagnostic, prognostic and therapeutic strategies against SARS CoV-2 .
The secondary objectives are
- Monitoring of viral replication of SARS-CoV-2 in the blood and respiratory tract in infected patients
- Monitoring of the humoral and cellular response directed against SARS-CoV-2
- Identification of factors leading to significant and / or prolonged viral replication of SARS-CoV-2 in the blood or respiratory samples
- Evaluation of the benefit of possible treatments implemented following the diagnosis of SARS-CoV-2 infection
- Exploration of the B and T immune repertoire sequences targeting SARS-CoV-2 in infected patients
- Typing of the HLA system in infected patients
Details
| Condition | SARS-CoV-2 |
|---|---|
| Age | 1-100 years |
| Clinical Study Identifier | NCT04405726 |
| Sponsor | University Hospital, Strasbourg, France |
| Last Modified on | 19 February 2024 |
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