Seroconversion Among Staff at a Large Acute Care Hospital in Denmark During the COVID-19 Pandemic
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- STATUS
- Recruiting
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- End date
- Aug 1, 2025
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- participants needed
- 300
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- sponsor
- Nordsjaellands Hospital
Summary
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital. This will enable the identification of those who are protected and non-infectious for SARS-CoV2 and those who are seronegative and therefore potentially susceptible and infectious on patient contact. Prospective testing will provide data on the acquisition of SARS-CoV2 infections among HCWs and associated risk factors for transmission during a pandemic at an acute care hospital facility in the capital region of Denmark.
Hypothesis: Serial seroconversion measurements in hospital employees improve the organization of the clinical treatment and care during the COVID-19 pandemic at Nordsjllands Hospital and Nykbing Falster County Hospital.
Description
The study is a prospective cohort study. Weekly (in the first phase) and bi-weekly (in the second phase) serum samples will be drawn and shipped bi-weekly to laboratory collaborators in United Kingdom for antibody analyses during the course of the local epidemic, expected to last 10-12 weeks or more. After the cease of the epidemic serum will be drawn in 3-monthly intervals in a smaller group of seroconverted volunteers to follow the long-lasting immunity of SARS-CoV-2 infection up to 5 years post-pandemic.
Nurses, medical doctors, biomedical laboratory scientists, social health care assistants, and few healthcare administrators (as controls) will be invited for enrolment. In hospitals, all departments with staff that are in physical contact with patients during the pandemic will be invited to participate in the study.
Details
| Condition | HOSPITAL PERSONNEL, Healthcare Provider, Covid 19 |
|---|---|
| Age | 18-100 years |
| Treatment | Serial seroconversion measurements in hospital employees during the COVID-19 pandemic |
| Clinical Study Identifier | NCT04431310 |
| Sponsor | Nordsjaellands Hospital |
| Last Modified on | 19 February 2024 |
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Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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