Myotonia and Muscle Stiffness in NMD

  • STATUS
    Recruiting
  • participants needed
    90
  • sponsor
    Klinikum der Universitaet Muenchen
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Updated on 19 February 2024
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stiffness
6 minute walk test
walk test
neuromuscular diseases
non-dystrophic myotonia
ultrasound hand

Summary

The primary objective of this study is to assess stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia. The secondary objectives are (1) to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia; to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with non-myotonic neuromuscular disorders, (3) assess correlations between to compare result values for stiffness, muscle tone, relaxation periods and elasticity with clinical muscle function tests, measured by clinical evaluation (MRC-scale) and the 6-minute walk test; (4) assess correlations between subcutaneous fat and muscle thickness and echogenicity, measured by muscle ultrasound and result values for stiffness, muscle tone, relaxation periods and elasticity.

Details
Condition Amyotonia Congenita
Age 18years - 100years
Treatment MyotonPro, Six-minute walk test, Semiquantitative muscle ultrasound, Hand-held Dynamometry of muscle strength
Clinical Study IdentifierNCT04411732
SponsorKlinikum der Universitaet Muenchen
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

For Patients
years of age
Confirmed neuromuscular disease
written consent
able and willing to perform study prodcedures
For healthy volunteers
age 18 years of age
written informed consent
no clinical sign for neuromuscular disorders

Exclusion Criteria

Severe comorbidities
Patient is participating in another clinical study using investigational treatment
Patient cannot perform required muscle function tests
the patient, in the opinion of the investigator, is unable to adhere to the requirements of the study
Clear my responses
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stiffness
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neuromuscular diseases
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ultrasound hand

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