A Study of CC-98633 BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells in Subjects With Relapsed and/or Refractory Multiple Myeloma
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- STATUS
- Recruiting
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- days left to enroll
- 76
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- participants needed
- 80
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- sponsor
- Juno Therapeutics, a Subsidiary of Celgene
Summary
This is a Phase 1, multicenter, open-label study of CC-98633, BCMA-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in subjects with relapsed and/or refractory multiple myeloma.
The study will consist of 2 parts: dose-escalation (Part A) and dose-expansion (Part B). The dose-escalation part (Part A) of the study is to evaluate the safety and tolerability of increasing dose levels of CC-98633 to establish a recommended Phase 2 dose (RP2D); and the dose-expansion part (Part B) of the study is to further evaluate the safety, pharmacokinetics/pharmacodynamics, and efficacy of CC-98633 at the RP2D.
Details
| Condition | Multiple Myeloma, Multiple Myeloma, Lymphoproliferative Disorder |
|---|---|
| Age | 18-100 years |
| Treatment | CC-98633 |
| Clinical Study Identifier | NCT04394650 |
| Sponsor | Juno Therapeutics, a Subsidiary of Celgene |
| Last Modified on | 19 February 2024 |
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