Correlation Between Oxidative Stress Status and COVID-19 Severity

  • STATUS
    Recruiting
  • participants needed
    90
  • sponsor
    Shahid Beheshti University of Medical Sciences
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Updated on 19 February 2024
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elisa
multiple organ failure

Summary

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Description

Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be checked by ELISA tests and compared between these two groups and healthy controls.

Details
Condition Physiological Stress, Stress, Oxidative Stress, Stress
Age 18years - 100years
Treatment Oxidative Stress ELISA Kit
Clinical Study IdentifierNCT04375137
SponsorShahid Beheshti University of Medical Sciences
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

more than 18 years old
positive RT-PCR COVID-19
compatible lung CT with COVID-19

Exclusion Criteria

not signing informed consent
using antioxidants
using statins
Clear my responses
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elisa
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