Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation
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- STATUS
- Recruiting
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- End date
- Jul 1, 2025
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- participants needed
- 140
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- sponsor
- St. Louis University
Summary
Delayed/slow graft function is the most common complication after kidney transplantation with an incidence over 20% and is the result of ischemia-reperfusion injury. The increased use of marginal kidney grafts to palliate the organ shortage is leading to a continued rise in the incidence of delayed/slow graft function. Delayed/slow graft function, however, is associated with an increased risk of acute rejection and graft failure. There are currently no clinically accepted biomarkers and no specific treatments for delayed/slow graft function. Regulatory T cells are protective in ischemia-reperfusion injury and rejection by suppressing pathologic immune responses. We hypothesize that the pre-transplant measurement of highly suppressive regulatory T cell is an accurate biomarker for delayed/slow graft function and its immunologic consequences. Ultimately, marginal kidney graft allocation could be directed to regulatory T cell-robust recipients and regulatory T cell-directed therapies could decrease marginal kidney graft discards without increasing delayed/slow graft function or impacting outcomes.
Details
| Condition | DGF, Kidney Transplant; Complications |
|---|---|
| Age | 18-100 years |
| Treatment | Highly suppressive Treg measurement |
| Clinical Study Identifier | NCT04414111 |
| Sponsor | St. Louis University |
| Last Modified on | 19 February 2024 |
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