TACE Combined With PD-1 Knockout Engineered T Cell in Advanced Hepatocellular Carcinoma.
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- STATUS
- Recruiting
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- participants needed
- 10
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- sponsor
- Central South University
Summary
This study will evaluate the safety and effect of transcatheter arterial chemoembolization (TACE)combined with percutaneous transhepatic PD-1 knockout engineered T cell infusion in the Paitents with advanced hepatocellular carcinoma(HCC). Blood and tissue samples will also be collected for research purposes.
Description
This is a clinical study to investigate the safety and effect of transcatheter arterial chemoembolization (TACE) in combination with PD-1 knockout engineered T cells in the Paitents with advanced hepatocellular carcinoma. TACE would block the blood supply of the tumor to achieve ischemic, hypoxic andnecrotic effects. The PD-1 knockout engineered T cells were also prepared from autologous origin using CRISPR Cas9 technology. The patients performed one TACE treatment followed by 3 cycles of PD-1 edited T cells by percutaneous infusion in the peripheral of tumor under the guide of CT every four weeks. The safety and clinical efficacy will be evaluated. biomarkers and immunological markers will be monitored.
Details
| Condition | Advanced Hepatocellular Carcinoma |
|---|---|
| Age | 18years - 70years |
| Treatment | Transcatheter arterial chemoembolization, PD-1 knockout engineered T cells |
| Clinical Study Identifier | NCT04417764 |
| Sponsor | Central South University |
| Last Modified on | 19 February 2024 |
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