The Role of MicroRNA in the Diagnosis Prognosis and Response to Treatment in Pancreatic Cancer

STATUS

Recruiting
End date

Apr 5, 2027
participants needed

100
sponsor

Western Connecticut Health Network

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Updated on 19 February 2024

See if I qualify

cancer

measurable disease

metastasis

adenocarcinoma

endocrine therapy

early diagnosis

carcinoma

pancreatic adenocarcinoma

metastatic pancreatic cancer

pancreaticoduodenectomy

systemic therapy

blood draw

adjuvant therapy

microrna

mirna

recurrent disease

malignancy

other malignancy

inoperable disease

pancreatic cancer

pancreatoduodenectomy

Summary

Show definitions

Aberrant miRNA production has been linked to a wide range of human cancers and shown to play important roles in their genesis and growth. These miRNA can be detected in the blood and tumors of patients with cancer. We hypothesize that the detection of certain miRNAs present in the blood/serum of patients with pancreatic cancer may be important to the early diagnosis of the disease. Furthermore, we hypothesize that miRNA detection in PC patients will yield prognostic information and help predict the response to treatment.

Details

Condition	Pancreatic Cancer, Pancreatic Cancer, Pancreatic disorder, Neoplasm of unspecified nature of digestive system, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV
Age	18years - 100years
Treatment	Blood Draw
Clinical Study Identifier	NCT04406831
Sponsor	Western Connecticut Health Network
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Have biopsy proven adenocarcinoma of the pancreas
	Have initially inoperable disease, classified as either locally advanced or metastatic disease
	Recurrent disease after a Whipple procedure is allowed
	Patients who are able to undergo resection after neoadjuvant therapy will continue to be followed after resection
	Have radiographically measurable disease
	Have an ECOG performance status of < 2
	Be willing to contribute the required information and specimens
	Provide written signed consent to participate
	Have received no prior anti-cancer treatments for metastatic pancreatic cancer
	Be eligible to receive multi-agent chemotherapy for the first line treatment of pancreatic cancer
	Have a predicted life expectancy of at least 3 months
	Not be concurrently receiving systemic therapy for another cancer except androgen deprivation therapy for stable/controlled prostate cancer
	No other active cancer except for: adequately treated local basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, superficial bladder cancer, asymptomatic prostate cancer without known metastatic disease and with no requirement for therapy or requiring only hormonal therapy and with normal prostate-specific antigen for >1 year prior to start of trial. Other adequately treated Stage 1 or 2 cancer currently in complete remission, or any other cancer that has been in complete remission for > 5 years is allowable

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The Role of MicroRNA in the Diagnosis Prognosis and Response to Treatment in Pancreatic Cancer