cfDNA Methylation Assay for Clinical Evaluation of Patients With Stage IA Lung Cancer After Ablation Operation

  • STATUS
    Recruiting
  • participants needed
    90
  • sponsor
    Shanghai Chest Hospital
Updated on 19 February 2024
cancer
lung cancer
ct scan chest
cfdna
chest ct

Summary

The objective is to screen and monitor the efficacy of cfDNA methylation in patients with stage I lung cancer after ablation, to compare the similarities and differences of cfDNA methylation between surgical treatment and ablation in patients with stage I lung cancer, and to look for new indicators to assess the efficacy of ablation therapy and to monitor lung cancer recurrence.

Description

The objective is to screen and monitor the efficacy of cfDNA methylation in patients with stage I lung cancer after ablation, to compare the similarities and differences of cfDNA methylation between surgical treatment and ablation in patients with stage I lung cancer, and to look for new indicators to assess the efficacy of ablation therapy and to monitor lung cancer recurrence.

The main research content is to screen the cfDNA methylation index that can monitor the efficacy of stage I lung cancer ablation and compare the similarities and differences of cfDNA methylation in patients with stage I lung cancer after surgery and ablation.

Details
Condition Pulmonary Disease, Lung Neoplasm, lung cancer, lung cancer
Age 18years - 85years
Treatment Surgery, Ablation
Clinical Study IdentifierNCT04413656
SponsorShanghai Chest Hospital
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Age: 18-85 years old
The peripheral pulmonary nodules found in patients with chest CT, preoperative examination showed that the clinical stage of patients was T1N0M0, IA
patients are not suitable for surgical treatment through multidisciplinary assessment, agree to accept ablation
Patients have good compliance with the tests and follow-ups, understand the situation of the study and sign informed consent

Exclusion Criteria

The patient is generally in poor condition and cannot tolerate the examination
patients with a cardiac pacemaker or stent in the heart; peripheral tumors of the lungs are adjacent to large blood vessels or important structures
patients with poor compliance
Researchers believe that it is not appropriate to participate in this trial
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