cfDNA Methylation Assay for Clinical Evaluation of Patients With Stage IA Lung Cancer After Ablation Operation

STATUS

Recruiting
participants needed

90
sponsor

Shanghai Chest Hospital

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Updated on 19 February 2024

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cancer

lung cancer

ct scan chest

cfdna

chest ct

Summary

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The objective is to screen and monitor the efficacy of cfDNA methylation in patients with stage I lung cancer after ablation, to compare the similarities and differences of cfDNA methylation between surgical treatment and ablation in patients with stage I lung cancer, and to look for new indicators to assess the efficacy of ablation therapy and to monitor lung cancer recurrence.

Description

The main research content is to screen the cfDNA methylation index that can monitor the efficacy of stage I lung cancer ablation and compare the similarities and differences of cfDNA methylation in patients with stage I lung cancer after surgery and ablation.

Details

Condition	Pulmonary Disease, Lung Neoplasm, lung cancer, lung cancer
Age	18years - 85years
Treatment	Surgery, Ablation
Clinical Study Identifier	NCT04413656
Sponsor	Shanghai Chest Hospital
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Age: 18-85 years old
	The peripheral pulmonary nodules found in patients with chest CT, preoperative examination showed that the clinical stage of patients was T1N0M0, IA
	patients are not suitable for surgical treatment through multidisciplinary assessment, agree to accept ablation
	Patients have good compliance with the tests and follow-ups, understand the situation of the study and sign informed consent
Exclusion Criteria
	The patient is generally in poor condition and cannot tolerate the examination
	patients with a cardiac pacemaker or stent in the heart; peripheral tumors of the lungs are adjacent to large blood vessels or important structures
	patients with poor compliance
	Researchers believe that it is not appropriate to participate in this trial

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cfDNA Methylation Assay for Clinical Evaluation of Patients With Stage IA Lung Cancer After Ablation Operation