IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION

  • STATUS
    Recruiting
  • End date
    Nov 15, 2026
  • participants needed
    3000
  • sponsor
    Johann Wolfgang Goethe University Hospital
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Updated on 19 February 2024
See if I qualify
heart disease
MRI
covid-19

Summary

Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR). These markers provide novel quantifiable imaging measures for myocardial tissue characterisation. Despite similar principles the measurements differ considerably between different sequences, vendors and field strengths, yielding a necessity to establish robust sequence-specific normal ranges, diagnostic accuracy and prognostic relationships in apparently healthy subjects with no known heart disease. A further unknown relates to separation between healthy myocardium and the subclinical disease in several groups of patients with suspected cardiac involvement. Examples include patients with systemic inflammatory conditions, as well as patients with a recent COVID-19 infection.

Details
Condition Heart failure, Heart failure, Heart disease, Heart disease, Cardiomyopathy, Cardiomyopathy, Myocarditis, Myocardial Fibrosis
Age 18years - 100years
Treatment CMR with T1 and T2 mapping
Clinical Study IdentifierNCT04444128
SponsorJohann Wolfgang Goethe University Hospital
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Able to provide informed consent
18 years of age and over
Absence of a valid clinical indication for CMR, including active cardiac symptoms and/or known or clinically relevant cardiac disease

Exclusion Criteria

accepted contraindications for a contrast-enhanced CMR study (in line with MRI safety and SmPC for contrast agent)
Clear my responses
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