IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
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- STATUS
- Recruiting
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- End date
- Nov 15, 2026
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- participants needed
- 3000
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- sponsor
- Johann Wolfgang Goethe University Hospital
Summary
Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR). These markers provide novel quantifiable imaging measures for myocardial tissue characterisation. Despite similar principles the measurements differ considerably between different sequences, vendors and field strengths, yielding a necessity to establish robust sequence-specific normal ranges, diagnostic accuracy and prognostic relationships in apparently healthy subjects with no known heart disease. A further unknown relates to separation between healthy myocardium and the subclinical disease in several groups of patients with suspected cardiac involvement. Examples include patients with systemic inflammatory conditions, as well as patients with a recent COVID-19 infection.
Details
| Condition | Heart failure, Heart failure, Heart disease, Heart disease, Cardiomyopathy, Cardiomyopathy, Myocarditis, Myocardial Fibrosis |
|---|---|
| Age | 18-100 years |
| Treatment | CMR with T1 and T2 mapping |
| Clinical Study Identifier | NCT04444128 |
| Sponsor | Johann Wolfgang Goethe University Hospital |
| Last Modified on | 19 February 2024 |
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