The Use of Indocyanine Green as a Diagnostic Adjunct for Pediatric Solid Malignancies
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- STATUS
- Recruiting
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- End date
- Jun 5, 2025
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- participants needed
- 45
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- sponsor
- Roshni Dasgupta
Summary
Use of indocyanine green will augment the accuracy of identification and resection of both primary solid malignancies as well as their pulmonary metastases, where applicable We will conduct a prospective feasibility study of pediatric patients with solid malignancies with or without lung metastatases who present at the time of initial diagnosis or relapse. These patients will receive a targeted dye to aid in the resection of these metastases. We plan to assess ICG as it relates to:
- Diagnostic accuracy using pathologic correlation as gold standard measure
- Short and long term event free and overall survival
Description
Patients diagnosed with solid malignancies or metastatic lesions who require clinically indicated resection will be identified by their Oncologist. The oncologist will inform the subject/family about the study and ask if they may be interested in participating. If the subject/family demonstrates potential interest in the study, the Pediatric Surgery Research team will discuss the risks and benefits of pre-operative ICG administration with the patients and enrollment.
Study subjects: All patients diagnosed with solid malignancies as well as those with metastatic disease distant from the primary tumor will be potentially eligible for the study. Diagnosis will be made:
- In a multimodal fashion including physical exam, radiologic evaluation (ultrasound, MRI, CT scan, etc), and sometimes biopsy.
- Prior to definitive surgical resection of the newly diagnosed malignancy
Details
| Condition | Metastasis, Brain Metastases, Liver Metastases, neoplasm metastasis, Brain Metastases, Liver Metastases, neoplasm metastasis, Primary Tumor, Solid Malignancies |
|---|---|
| Age | 45 years and younger |
| Clinical Study Identifier | NCT04492735 |
| Sponsor | Roshni Dasgupta |
| Last Modified on | 19 February 2024 |
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