Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins
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- STATUS
- Recruiting
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- End date
- Jul 14, 2025
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- participants needed
- 340
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- sponsor
- University of Colorado, Denver
Summary
The study is designed to learn more about the causes of
Description
The Specific Aims of This Study Are As Follows:
- Identify whether sputum
anti-CCP predicts incident RA - Determine the effect of inflammatory
cytokines on the induction of NETosis in sputumneutrophils - Determine the role of sputum macrophage phagocytosis in NET clearance <br> The knowledge gained from this study will improve the overall understanding of the development of RA. It is anticipated that these findings will improve the field's understanding of how best to screen for RA risk and target RA prevention. This study could support future lung-targeted prevention strategies for RA that could avoid the administration of systemic toxic therapies. Such potential prevention interventions could be implemented in subjects at risk for RA in order to prevent the irreversible joint damage that can occur in the later stages of clinically-apparent RA.
Details
| Condition |
|
|---|---|
| Age | 18years - 100years |
| Treatment | N/A (Observational Study) |
| Clinical Study Identifier | NCT04474392 |
| Sponsor | University of Colorado, Denver |
| Last Modified on | 19 February 2024 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
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