Treatment of Critically Ill Patients With Covid-19 With Convalescent Plasma

  • STATUS
    Recruiting
  • participants needed
    36
  • sponsor
    Hospital de Infecciosas Francisco Javier Muniz
Updated on 19 February 2024
critical illness
shock
organ failure
mechanical ventilation
respiratory distress
acute respiratory distress syndrome
covid-19
critically ill
acute respiratory distress

Summary

This study aims to collect convalescent plasma and use it as experimental treatment in critically ill Covid-19 patients in order to reduce mortality and length of stay in intensive care unit.

Description

This study aims to use convalescent plasma as experimental treatment in critically ill Covid-19 patients in order to reduce mortality and length of stay in intensive care unit. Donors must have anti-SARS CoV2 antibodies. Recipients must be critically ill Covid-19 patients on mechanical ventilation.

Details
Condition SARS coronavirus, Severe Acute Respiratory Syndrome, COVID19
Age 18-100 years
Treatment Convalescent plasma
Clinical Study IdentifierNCT04468009
SponsorHospital de Infecciosas Francisco Javier Muniz
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Age: 18 years or more
Patient with Covid-19 confirmed with nuclear acid testing
Critically ill patients with Covid-19 on mechanical ventilation. Potencially critically ill patients (with acute respiratory distress syndrome, septic shock and/or multiple organ failure) with Covid-19
Diagnosed with acute respiratory distress syndrome
Informed consent

Exclusion Criteria

No consent
Symptoms for a period longer than 20 days
Not detectable by acid nuclear testing within 48 hours prior to elegibility
Descompensated congestive heart failure, in which receiving 500ml of intrasvascular volume signifies a life risk
History of severe adverse events or anaphylaxis to plasma components
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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