Modality of Adjuvant Radiotherapy and Chemotherapy for Stage Endometrial Cancer
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- STATUS
- Recruiting
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- End date
- Apr 5, 2027
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- participants needed
- 654
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- sponsor
- Peking University People's Hospital
Summary
Endometrial cancer is the most common gynecological malignancy affecting women's health. About 15% of the patients will have local late disease (stage III) with high risk of recurrence and tumor related mortality. There is a consensus that adjuvant radiochemotherapy is needed for stage endometrial cancer, but the best modality of radiochemotherapy is still uncertain. The retrospective data of our center showed that the sequential radiochemotherapy of "chemotherapy-radiotherapy-chemotherapy" in the "sanwich" mode could improve the survival outcome in patients with advanced endometrial cancer. A multicenter, prospective, randomized controlled study to compare the "sanwich" mode of radiochemotherapy and the "concurrent chemoradiotherapy followed by chemotherapy" mode will be carried out to determine the better modality of radiochemotherapy in stage III endometrial adenocarcinoma.
Details
| Condition | Endometrial Carcinoma, endometrial cancer, Uterine Cancer, Uterine Cancer, endometrial cancer |
|---|---|
| Age | 100 years and younger |
| Treatment | sequential radiochemotherapy in a "sanwich" mode |
| Clinical Study Identifier | NCT04453904 |
| Sponsor | Peking University People's Hospital |
| Last Modified on | 19 February 2024 |
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